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In the new review, we noted the identification and also the characterization of a whole new atypical opioid receptor with exceptional damaging regulatory Qualities in the direction of opioid peptides.one Our results confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a wide-spectrum s